We're at 341 East 62nd Street, in Lenox Hill on the Upper East Side. There's no lobby and no front desk, so the only thing you really need to know before you arrive is how to get to the door. Here's how each airport actually shakes out, plus the trains once you're settled in.
From LaGuardia (LGA): the easy one
LaGuardia is your fastest option, usually 25 to 40 minutes by car depending on traffic on the Grand Central Parkway and the RFK Bridge. A yellow cab or rideshare drops you right at the door on 62nd Street. There's no flat fare from LGA the way there is from JFK, so expect roughly $40 to $70 plus tolls and tip. If you land at rush hour, pad it out toward the high end.
There's no one-seat subway ride from LaGuardia, so if you're set on transit you'd take the Q70 bus to the subway, which is more hassle than it's worth with luggage. For LGA, just take the car.
From JFK: budget the time
From JFK, a taxi to Manhattan is a flat $70 metered fare plus tolls, tip, and a peak surcharge, and the ride is 45 to 75 minutes depending on the Van Wyck. Rideshare is often similar or a touch more at busy times.
If you'd rather take transit, the AirTrain to Jamaica connects to the E train, which gets you to Midtown; from there you'd transfer to reach the Upper East Side. It's cheaper but slower and involves stairs and a transfer or two. With bags after a long flight, we'd take the car. Without much luggage, the train is fine.
From Newark (EWR): allow extra
Newark is in New Jersey, so a car runs 45 to 80 minutes and the fare is the highest of the three once you add the tolls and the New Jersey surcharge, often $80 to $110 all in. The AirTrain plus NJ Transit into Penn Station is the transit route, and from Penn you'd take the subway across and up to us. Doable, but it's the longest haul. If your flight choice is flexible, LaGuardia is the least stressful way in.
The closest subway once you're here
The closest station is Lexington Av/63 St, served by the F and Q lines, about a 7-minute walk from the front door. The Q runs straight up Second Avenue and down to Midtown and beyond, which makes it genuinely useful day to day.
A little further is the big Lexington Av/59 St complex with the 4, 5, 6, N, R, and W trains, roughly a 10-minute walk. The 6 is your local for hops up and down the East Side; the 4 and 5 are the expresses; the N, R, and W run over to Midtown and down toward Brooklyn. Between those two stations you can get just about anywhere in the city without a transfer.
A few practical notes
Give the driver "341 East 62nd Street, between First and Second Avenue." It's a quiet residential block, which is the point, but it means it's not a landmark a driver will know by name. There's no doorman to flag down, so when you're a few minutes out, text us and we'll make sure you've got the door code and know exactly which door is yours. Come and go as you please after that. No key card, just your own front door.
If you're weighing the train against a car, the honest rule is luggage and time of day. Off-peak with a carry-on, the subway is quick and cheap. Rush hour with two suitcases, take the car and read your phone.